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CBD and Blood Thinning Medication

The reason for not using pure CBD oil with blood thinners has nothing to do with it ‘thinning your blood.’ It has to do with the fact that CBD is a powerful inhibitor of the liver enzyme that metabolizes blood thinners (and some other medications). The enzyme is called CYP3A4. If this enzyme is inhibited it could allow more of the drug to enter your systemic bloodstream than normal.

Normally, you swallow a medication, it goes through your stomach and into the small intestine. Then it goes into your bloodstream and passes through the liver. Enzymes inside the liver break the medication down. For most drugs, much of the dose is destroyed, something called the first pass effect. If you have enough pure CBD oil in your system, it binds to the end of the enzyme protein chain known as the catalytic or active site. (This is temporary, as in for only a few hours after ingesting CBD, but should still be taken under advisement.) If the pure CBD oil is bound to the enzymes at the time, they can’t bind to the molecules of the medication passing through your liver. So instead of a large part of the medication being broken down, it passes unchanged into your systemic bloodstream.

This could lead to an overdose of this medication. With something like Warfarin or other blood thinners, that could lead to uncontrolled bleeding around your heart, in your eye, brain, abdomen or spine. This is not something to be trifled with. Theoretically, you could mix the two but it would need to be done WITH THE STRICT KNOWLEDGE, CONSENT AND SUPERVISION OF A DOCTOR. Don’t go by the guidelines of “Oh yeah, I mix CBD and this medication and I’m fine.” This could literally get you killed.

So make sure you see your GP to inform,  that you would like to start taking CBD oil and that your blood needs to be monitored regularly.